پاورپوینت لوسمی حاد ومزمن
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لوسمی حاد ومزمن
uThe myeloid leukemias are a heterogeneous group of diseases characterized by infiltration of the blood, bone marrow, and other tissues by neoplastic cells of the hematopoietic system
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Etiology
trisomy 21 .. Inherited diseases with defective DNA repair, e.g., Fanconi anemia, Bloom syndrome, and ataxia-telangiectasia, . Congenital neutropenia (Kostmann syndrome)
uRadiation
Exposure to benzene,
=Anticancer drugs. Alkylating agent–associated leukemias occur on average 4–۶ years after exposure, and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase II inhibitor–associated leukemias occur 1–۳ years after exposure, and affected individuals often have aberrations involving chromosome 11q23. Chloramphenicol, phenylbutazone, and, less commonly, chloroquine and methoxypsoralen
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